Effects of grapefruit juice on the pharmacokinetics of selected CYP 3 A 4 substrate drugs
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منابع مشابه
Effect of oral co-administration of frozen-dried grapefruit juice on pharmacokinetics of tramadol in dogs
Tramadol is a centrally acting analgesic drug extensively metabolized in animal species. Its clinicalresponse is mainly due to the M1 metabolite, poorly produced in dogs. Grapefruit-juice can inhibit themetabolism of different drugs in animals and humans. The aim of the present study was to evaluate thepharmacokinetics of tramadol and its major metabolites after co-administration of tramadol an...
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Concomitant administration of grapefruit juice can increase the plasma concentration of numerous drugs in humans and decrease the concentration of a few others. Such elevations of drug plasma concentrations have, on occasion, resulted in adverse clinical effects. Increased concentrations are primarily mediated by chemicals in grapefruit juice, which inhibit the CYP 3A4 drug-metabolizing enzyme ...
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Grapefruit juice is consumed widely in today's health conscious world as a protector against cardiovascular diseases and cancers. It has however, been found to be an inhibitor of the intestinal cytochrome P - 450 3A4 system, which is responsible for the first pass metabolism of many drugs. The P - glycoprotein pump, found in the brush border of the intestinal wall which transports many of these...
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The effect of grapefruit juice and liqorice juice on salivary pharmacokinetics of paracetamol (acetaminophen, APAP) in 8 healthy subjects (4 males and 4 females) was investigated. Paracetamol tablet (500 mg) was administered to the volunteers with either 240 mL grapefruit juice, licorice juice or water followed by saliva samples collection at different time intervals in a sequential study desig...
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This study was designed to investigate the effects of tangerine, orange, and grapefruit juice on the pharmacokinetic pattern of cyclosporine A in rats. Forty male Sprague-Dawley rats were divided into four groups to receive water, orange, tangerine, or grapefruit juices respectively. Water or juices (10 ml/kg) were given orally twice a day for 3 days. Three hours after the 5th dose, cyclosporin...
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